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Word and Excel slow to open on TS 2012 R2

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Hi guys,

i have an issue with one of our deployed servers, some times we get a call saying that the performance is poor for word and excel. it takes up to 1 min to open, whether opening from start menu or by opening an existing document (size of the document is irrelevant<1MB - 10MB).

List of things I've ruled out/done

User load issues is irrelevant has happened with 5 users and happened with 30 users.

i'm sure its not resources:

2X E5-2650 @2.3GHz = total 40 cores
128GB of RAM
4X300GB 15K SAS HDD raid 5 + hotspare
have reinstalled office.

hardware acceleration for office graphics is disabled.

office is 2013 PP 32-bit

happens with files that are stored locally or over the network 

DOSE NOT happen as admin

DOSE NOT happen when run in safemode

when the issues is happening it affects everyone

it starts and stops happening with no cause 

if any can give me any advice or if you have any questions please let me know 

thanks

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